5cox Summary

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UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)

The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (Q05769) inflammatory responsesearch oxidation-reduction processsearch brown fat cell differentiationsearch response to vitamin Dsearch response to glucocorticoidsearch response to cytokinesearch maintenance of blood-brain barriersearch regulation of cell proliferationsearch keratinocyte differentiationsearch positive regulation of cell proliferationsearch decidualizationsearch angiogenesissearch positive regulation of smooth muscle cell proliferationsearch response to organic substancesearch negative regulation of smooth muscle contractionsearch learningsearch bone mineralizationsearch response to radiationsearch response to lithium ionsearch positive regulation of NF-kappaB import into nucleussearch memorysearch cellular response to ATPsearch sensory perception of painsearch positive regulation of smooth muscle contractionsearch cyclooxygenase pathwaysearch response to fatty acidsearch prostaglandin biosynthetic processsearch negative regulation of synaptic transmission, dopaminergicsearch response to fructosesearch response to estradiolsearch response to drugsearch positive regulation of platelet-derived growth factor productionsearch lipid metabolic processsearch negative regulation of cell proliferationsearch negative regulation of calcium ion transportsearch embryo implantationsearch cellular response to UVsearch positive regulation of apoptotic processsearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of brown fat cell differentiationsearch positive regulation of transforming growth factor beta productionsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch positive regulation of fever generationsearch ovulationsearch response to manganese ionsearch response to lipopolysaccharidesearch hair cyclesearch fatty acid biosynthetic processsearch positive regulation of cell deathsearch positive regulation of synaptic plasticitysearch negative regulation of cell cyclesearch positive regulation of vascular endothelial growth factor productionsearch fatty acid metabolic processsearch positive regulation of fibroblast growth factor productionsearch positive regulation of vasoconstrictionsearch cellular response to mechanical stimulussearch cellular response to fluid shear stresssearch prostaglandin metabolic processsearch response to organic cyclic compoundsearch response to organonitrogen compoundsearch positive regulation of synaptic transmission, glutamatergicsearch cellular response to hypoxiasearch response to tumor necrosis factorsearch response to oxidative stresssearch peroxidase activitysearch heme bindingsearch metal ion bindingsearch prostaglandin-endoperoxide synthase activitysearch protein homodimerization activitysearch oxidoreductase activitysearch lipid bindingsearch dioxygenase activitysearch enzyme bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch intracellular membrane-bounded organellesearch neuron projectionsearch cytoplasmsearch membranesearch caveolasearch organelle membranesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch protein complexsearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search