5cox Summary



The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (Q05769) response to oxidative stresssearch regulation of cell proliferationsearch positive regulation of platelet-derived growth factor productionsearch cellular response to hypoxiasearch response to lithium ionsearch response to cytokinesearch decidualizationsearch positive regulation of vasoconstrictionsearch lipid metabolic processsearch response to organic cyclic compoundsearch response to organic substancesearch positive regulation of fever generationsearch bone mineralizationsearch positive regulation of synaptic plasticitysearch prostaglandin biosynthetic processsearch regulation of blood pressuresearch fatty acid biosynthetic processsearch cellular response to mechanical stimulussearch memorysearch sensory perception of painsearch positive regulation of apoptotic processsearch prostaglandin metabolic processsearch positive regulation of smooth muscle cell proliferationsearch negative regulation of synaptic transmission, dopaminergicsearch response to fatty acidsearch positive regulation of nitric oxide biosynthetic processsearch negative regulation of cell proliferationsearch fatty acid metabolic processsearch positive regulation of transforming growth factor beta productionsearch cyclooxygenase pathwaysearch embryo implantationsearch negative regulation of calcium ion transportsearch positive regulation vascular endothelial growth factor productionsearch positive regulation of smooth muscle contractionsearch response to fructosesearch ovulationsearch response to tumor necrosis factorsearch cellular response to ATPsearch response to lipopolysaccharidesearch positive regulation of cell proliferationsearch angiogenesissearch negative regulation of cell cyclesearch response to glucocorticoidsearch positive regulation of brown fat cell differentiationsearch response to vitamin Dsearch response to radiationsearch learningsearch hair cyclesearch inflammatory responsesearch maintenance of blood-brain barriersearch oxidation-reduction processsearch response to manganese ionsearch positive regulation of cell deathsearch cellular response to UVsearch positive regulation of NF-kappaB import into nucleussearch positive regulation of fibroblast growth factor productionsearch response to organonitrogen compoundsearch negative regulation of smooth muscle contractionsearch positive regulation of cell migration involved in sprouting angiogenesissearch response to estradiolsearch response to drugsearch positive regulation of synaptic transmission, glutamatergicsearch brown fat cell differentiationsearch keratinocyte differentiationsearch heme bindingsearch peroxidase activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch protein homodimerization activitysearch prostaglandin-endoperoxide synthase activitysearch oxidoreductase activitysearch lipid bindingsearch enzyme bindingsearch dioxygenase activitysearch metal ion bindingsearch cytoplasmsearch endoplasmic reticulum membranesearch endoplasmic reticulumsearch neuron projectionsearch intracellular membrane-bounded organellesearch protein complexsearch membranesearch caveolasearch organelle membranesearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search