5cox Summary

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UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)

The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (Q05769) heme bindingsearch prostaglandin-endoperoxide synthase activitysearch oxidoreductase activitysearch dioxygenase activitysearch protein homodimerization activitysearch lipid bindingsearch peroxidase activitysearch metal ion bindingsearch enzyme bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch response to oxidative stresssearch regulation of cell proliferationsearch keratinocyte differentiationsearch positive regulation of smooth muscle contractionsearch positive regulation of fever generationsearch brown fat cell differentiationsearch cellular response to mechanical stimulussearch response to organonitrogen compoundsearch bone mineralizationsearch negative regulation of calcium ion transportsearch maintenance of blood-brain barriersearch positive regulation of NF-kappaB import into nucleussearch response to organic substancesearch cellular response to UVsearch negative regulation of cell proliferationsearch decidualizationsearch learningsearch memorysearch response to lithium ionsearch positive regulation of cell proliferationsearch cyclooxygenase pathwaysearch positive regulation of synaptic plasticitysearch negative regulation of cell cyclesearch lipid metabolic processsearch negative regulation of synaptic transmission, dopaminergicsearch regulation of blood pressuresearch embryo implantationsearch hair cyclesearch inflammatory responsesearch prostaglandin biosynthetic processsearch response to cytokinesearch positive regulation of vasoconstrictionsearch positive regulation of nitric oxide biosynthetic processsearch response to fructosesearch positive regulation of smooth muscle cell proliferationsearch positive regulation of platelet-derived growth factor productionsearch positive regulation vascular endothelial growth factor productionsearch fatty acid biosynthetic processsearch positive regulation of transforming growth factor beta productionsearch cellular response to fluid shear stresssearch ovulationsearch response to lipopolysaccharidesearch cellular response to hypoxiasearch positive regulation of fibroblast growth factor productionsearch response to organic cyclic compoundsearch response to estradiolsearch positive regulation of synaptic transmission, glutamatergicsearch positive regulation of brown fat cell differentiationsearch response to manganese ionsearch response to glucocorticoidsearch positive regulation of apoptotic processsearch positive regulation of cell deathsearch response to drugsearch response to vitamin Dsearch negative regulation of smooth muscle contractionsearch sensory perception of painsearch oxidation-reduction processsearch prostaglandin metabolic processsearch fatty acid metabolic processsearch response to fatty acidsearch positive regulation of cell migration involved in sprouting angiogenesissearch angiogenesissearch response to tumor necrosis factorsearch response to radiationsearch cellular response to ATPsearch neuron projectionsearch membranesearch cytoplasmsearch protein complexsearch endoplasmic reticulumsearch intracellular membrane-bounded organellesearch caveolasearch organelle membranesearch endoplasmic reticulum membranesearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search