5cox Summary

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UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)

The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (Q05769) regulation of cell proliferationsearch response to lithium ionsearch positive regulation of fibroblast growth factor productionsearch positive regulation of fever generationsearch response to tumor necrosis factorsearch positive regulation of brown fat cell differentiationsearch prostaglandin biosynthetic processsearch positive regulation of transforming growth factor beta productionsearch inflammatory responsesearch response to manganese ionsearch response to organic substancesearch sensory perception of painsearch oxidation-reduction processsearch positive regulation of cell deathsearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation vascular endothelial growth factor productionsearch response to estradiolsearch cellular response to UVsearch maintenance of blood-brain barriersearch positive regulation of platelet-derived growth factor productionsearch positive regulation of NF-kappaB import into nucleussearch negative regulation of smooth muscle contractionsearch cellular response to ATPsearch positive regulation of synaptic transmission, glutamatergicsearch cyclooxygenase pathwaysearch response to lipopolysaccharidesearch response to vitamin Dsearch hair cyclesearch positive regulation of smooth muscle contractionsearch response to organonitrogen compoundsearch response to oxidative stresssearch regulation of blood pressuresearch learningsearch keratinocyte differentiationsearch anagensearch angiogenesissearch positive regulation of apoptotic processsearch positive regulation of synaptic plasticitysearch cellular response to hypoxiasearch lipid metabolic processsearch negative regulation of cell cyclesearch bone mineralizationsearch response to cytokinesearch brown fat cell differentiationsearch negative regulation of synaptic transmission, dopaminergicsearch fatty acid metabolic processsearch positive regulation of vasoconstrictionsearch negative regulation of cell proliferationsearch decidualizationsearch response to fatty acidsearch response to drugsearch response to glucocorticoidsearch response to organic cyclic compoundsearch memorysearch positive regulation of smooth muscle cell proliferationsearch cellular response to mechanical stimulussearch embryo implantationsearch positive regulation of nitric oxide biosynthetic processsearch ovulationsearch negative regulation of calcium ion transportsearch response to fructosesearch prostaglandin metabolic processsearch response to radiationsearch fatty acid biosynthetic processsearch neuron projectionsearch endoplasmic reticulum membranesearch membranesearch protein complexsearch organelle membranesearch intracellular membrane-bounded organellesearch endoplasmic reticulumsearch cytoplasmsearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch lipid bindingsearch oxidoreductase activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch protein homodimerization activitysearch enzyme bindingsearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search