5cox Summary



The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (Q05769) prostaglandin biosynthetic processsearch inflammatory responsesearch learningsearch response to cytokine stimulussearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch response to oxidative stresssearch positive regulation of synaptic transmission, glutamatergicsearch response to fatty acidsearch response to glucocorticoid stimulussearch hair cyclesearch positive regulation of cell deathsearch response to organic cyclic compoundsearch negative regulation of calcium ion transportsearch positive regulation of transforming growth factor beta productionsearch bone mineralizationsearch lipid metabolic processsearch cellular response to mechanical stimulussearch positive regulation of synaptic plasticitysearch response to tumor necrosis factorsearch negative regulation of cell proliferationsearch regulation of blood pressuresearch positive regulation of fibroblast growth factor productionsearch cellular response to UVsearch cyclooxygenase pathwaysearch positive regulation of platelet-derived growth factor productionsearch anagensearch response to organic substancesearch positive regulation of cell migration involved in sprouting angiogenesissearch maintenance of blood-brain barriersearch fatty acid metabolic processsearch regulation of cell proliferationsearch response to lipopolysaccharidesearch positive regulation of smooth muscle cell proliferationsearch response to vitamin Dsearch response to radiationsearch positive regulation of NF-kappaB import into nucleussearch brown fat cell differentiationsearch positive regulation of vasoconstrictionsearch positive regulation of smooth muscle contractionsearch response to organonitrogen compoundsearch positive regulation of apoptotic processsearch response to lithium ionsearch decidualizationsearch negative regulation of cell cyclesearch sensory perception of painsearch prostaglandin metabolic processsearch cellular response to ATPsearch embryo implantationsearch positive regulation of fever generationsearch positive regulation vascular endothelial growth factor productionsearch cellular response to hypoxiasearch keratinocyte differentiationsearch fatty acid biosynthetic processsearch response to estradiol stimulussearch response to drugsearch positive regulation of brown fat cell differentiationsearch ovulationsearch negative regulation of synaptic transmission, dopaminergicsearch angiogenesissearch response to fructose stimulussearch memorysearch response to manganese ionsearch negative regulation of smooth muscle contractionsearch heme bindingsearch peroxidase activitysearch enzyme bindingsearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch metal ion bindingsearch oxidoreductase activitysearch lipid bindingsearch protein homodimerization activitysearch intracellular membrane-bounded organellesearch endoplasmic reticulum membranesearch membranesearch cytoplasmsearch organelle membranesearch protein complexsearch neuron projectionsearch endoplasmic reticulumsearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidase, animalsearch Haem peroxidasesearch Haem peroxidase, animal, subgroupsearch