5cox Summary

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UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)

The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (Q05769) keratinocyte differentiationsearch response to manganese ionsearch positive regulation of transforming growth factor beta productionsearch fatty acid metabolic processsearch regulation of cell proliferationsearch positive regulation of vasoconstrictionsearch ovulationsearch oxidation-reduction processsearch brown fat cell differentiationsearch sensory perception of painsearch response to organic substancesearch prostaglandin biosynthetic processsearch positive regulation of NF-kappaB import into nucleussearch response to drugsearch positive regulation of apoptotic processsearch positive regulation of nitric oxide biosynthetic processsearch prostaglandin metabolic processsearch inflammatory responsesearch positive regulation of smooth muscle contractionsearch positive regulation of synaptic transmission, glutamatergicsearch response to glucocorticoidsearch response to organic cyclic compoundsearch bone mineralizationsearch decidualizationsearch regulation of blood pressuresearch cellular response to hypoxiasearch negative regulation of cell proliferationsearch lipid metabolic processsearch negative regulation of smooth muscle contractionsearch positive regulation of smooth muscle cell proliferationsearch hair cyclesearch response to estradiolsearch positive regulation of fibroblast growth factor productionsearch positive regulation of fever generationsearch cellular response to ATPsearch cyclooxygenase pathwaysearch response to radiationsearch cellular response to UVsearch cellular response to mechanical stimulussearch embryo implantationsearch positive regulation of cell proliferationsearch angiogenesissearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of synaptic plasticitysearch negative regulation of calcium ion transportsearch positive regulation of cell deathsearch response to fructosesearch positive regulation vascular endothelial growth factor productionsearch negative regulation of cell cyclesearch response to cytokinesearch fatty acid biosynthetic processsearch positive regulation of brown fat cell differentiationsearch positive regulation of platelet-derived growth factor productionsearch learningsearch maintenance of blood-brain barriersearch response to vitamin Dsearch response to fatty acidsearch response to tumor necrosis factorsearch response to lithium ionsearch response to organonitrogen compoundsearch response to lipopolysaccharidesearch negative regulation of synaptic transmission, dopaminergicsearch memorysearch response to oxidative stresssearch protein complexsearch neuron projectionsearch endoplasmic reticulumsearch cytoplasmsearch intracellular membrane-bounded organellesearch caveolasearch membranesearch organelle membranesearch endoplasmic reticulum membranesearch prostaglandin-endoperoxide synthase activitysearch protein homodimerization activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch metal ion bindingsearch lipid bindingsearch heme bindingsearch peroxidase activitysearch dioxygenase activitysearch enzyme bindingsearch oxidoreductase activitysearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search