5cox Summary



The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (Q05769) cyclooxygenase pathwaysearch negative regulation of cell cyclesearch prostaglandin biosynthetic processsearch response to lithium ionsearch response to fatty acidsearch inflammatory responsesearch regulation of cell proliferationsearch positive regulation of cell deathsearch response to lipopolysaccharidesearch positive regulation of platelet-derived growth factor productionsearch positive regulation of cell proliferationsearch positive regulation of fever generationsearch positive regulation of nitric oxide biosynthetic processsearch response to manganese ionsearch memorysearch cellular response to UVsearch positive regulation of brown fat cell differentiationsearch negative regulation of smooth muscle contractionsearch cellular response to ATPsearch positive regulation vascular endothelial growth factor productionsearch fatty acid metabolic processsearch response to oxidative stresssearch cellular response to hypoxiasearch positive regulation of NF-kappaB import into nucleussearch learningsearch maintenance of blood-brain barriersearch oxidation-reduction processsearch positive regulation of smooth muscle contractionsearch negative regulation of synaptic transmission, dopaminergicsearch positive regulation of fibroblast growth factor productionsearch negative regulation of calcium ion transportsearch fatty acid biosynthetic processsearch decidualizationsearch positive regulation of transforming growth factor beta productionsearch response to glucocorticoidsearch prostaglandin metabolic processsearch cellular response to mechanical stimulussearch response to organic substancesearch response to estradiolsearch regulation of blood pressuresearch keratinocyte differentiationsearch positive regulation of vasoconstrictionsearch response to tumor necrosis factorsearch hair cyclesearch bone mineralizationsearch embryo implantationsearch brown fat cell differentiationsearch response to radiationsearch response to fructosesearch positive regulation of cell migration involved in sprouting angiogenesissearch ovulationsearch positive regulation of synaptic plasticitysearch negative regulation of cell proliferationsearch lipid metabolic processsearch positive regulation of smooth muscle cell proliferationsearch positive regulation of apoptotic processsearch response to drugsearch response to vitamin Dsearch response to organonitrogen compoundsearch angiogenesissearch response to cytokinesearch response to organic cyclic compoundsearch positive regulation of synaptic transmission, glutamatergicsearch sensory perception of painsearch metal ion bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch enzyme bindingsearch prostaglandin-endoperoxide synthase activitysearch oxidoreductase activitysearch heme bindingsearch lipid bindingsearch peroxidase activitysearch protein homodimerization activitysearch dioxygenase activitysearch intracellular membrane-bounded organellesearch protein complexsearch neuron projectionsearch endoplasmic reticulum membranesearch cytoplasmsearch caveolasearch membranesearch endoplasmic reticulumsearch organelle membranesearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search