5cox Summary

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UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)

The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (Q05769) heme bindingsearch lipid bindingsearch protein homodimerization activitysearch prostaglandin-endoperoxide synthase activitysearch peroxidase activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch dioxygenase activitysearch oxidoreductase activitysearch enzyme bindingsearch metal ion bindingsearch keratinocyte differentiationsearch regulation of cell proliferationsearch response to drugsearch brown fat cell differentiationsearch cellular response to mechanical stimulussearch prostaglandin biosynthetic processsearch positive regulation of NF-kappaB import into nucleussearch response to estradiolsearch positive regulation vascular endothelial growth factor productionsearch fatty acid biosynthetic processsearch bone mineralizationsearch response to organic substancesearch negative regulation of cell proliferationsearch negative regulation of cell cyclesearch positive regulation of nitric oxide biosynthetic processsearch cellular response to UVsearch angiogenesissearch inflammatory responsesearch response to organonitrogen compoundsearch maintenance of blood-brain barriersearch embryo implantationsearch positive regulation of apoptotic processsearch negative regulation of synaptic transmission, dopaminergicsearch positive regulation of transforming growth factor beta productionsearch cyclooxygenase pathwaysearch regulation of blood pressuresearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of cell deathsearch learningsearch positive regulation of smooth muscle contractionsearch response to manganese ionsearch response to fructosesearch positive regulation of vasoconstrictionsearch response to radiationsearch positive regulation of fever generationsearch prostaglandin metabolic processsearch response to vitamin Dsearch decidualizationsearch oxidation-reduction processsearch response to tumor necrosis factorsearch negative regulation of smooth muscle contractionsearch positive regulation of platelet-derived growth factor productionsearch positive regulation of synaptic plasticitysearch negative regulation of calcium ion transportsearch positive regulation of fibroblast growth factor productionsearch positive regulation of smooth muscle cell proliferationsearch response to organic cyclic compoundsearch positive regulation of synaptic transmission, glutamatergicsearch hair cyclesearch sensory perception of painsearch positive regulation of brown fat cell differentiationsearch lipid metabolic processsearch cellular response to hypoxiasearch response to glucocorticoidsearch ovulationsearch memorysearch response to lithium ionsearch response to cytokinesearch response to fatty acidsearch cellular response to ATPsearch response to lipopolysaccharidesearch response to oxidative stresssearch fatty acid metabolic processsearch neuron projectionsearch intracellular membrane-bounded organellesearch cytoplasmsearch endoplasmic reticulumsearch membranesearch protein complexsearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search