5cox Summary



The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (Q05769) oxidation-reduction processsearch negative regulation of synaptic transmission, dopaminergicsearch cellular response to UVsearch positive regulation of vasoconstrictionsearch brown fat cell differentiationsearch regulation of cell proliferationsearch positive regulation of NF-kappaB import into nucleussearch positive regulation of cell deathsearch keratinocyte differentiationsearch response to lipopolysaccharidesearch response to estradiolsearch response to tumor necrosis factorsearch response to cytokinesearch angiogenesissearch positive regulation of platelet-derived growth factor productionsearch anagensearch positive regulation of smooth muscle cell proliferationsearch inflammatory responsesearch regulation of blood pressuresearch fatty acid metabolic processsearch cyclooxygenase pathwaysearch hair cyclesearch response to organonitrogen compoundsearch response to organic cyclic compoundsearch negative regulation of cell proliferationsearch bone mineralizationsearch memorysearch positive regulation of fibroblast growth factor productionsearch positive regulation of smooth muscle contractionsearch ovulationsearch cellular response to mechanical stimulussearch cellular response to ATPsearch response to organic substancesearch response to lithium ionsearch positive regulation of nitric oxide biosynthetic processsearch prostaglandin biosynthetic processsearch positive regulation of brown fat cell differentiationsearch response to fatty acidsearch negative regulation of calcium ion transportsearch response to vitamin Dsearch response to radiationsearch fatty acid biosynthetic processsearch positive regulation vascular endothelial growth factor productionsearch prostaglandin metabolic processsearch decidualizationsearch response to fructosesearch positive regulation of transforming growth factor beta productionsearch embryo implantationsearch response to glucocorticoidsearch positive regulation of fever generationsearch cellular response to hypoxiasearch negative regulation of cell cyclesearch sensory perception of painsearch positive regulation of synaptic plasticitysearch maintenance of blood-brain barriersearch negative regulation of smooth muscle contractionsearch positive regulation of synaptic transmission, glutamatergicsearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of apoptotic processsearch response to drugsearch response to manganese ionsearch lipid metabolic processsearch learningsearch response to oxidative stresssearch peroxidase activitysearch heme bindingsearch enzyme bindingsearch prostaglandin-endoperoxide synthase activitysearch metal ion bindingsearch protein homodimerization activitysearch lipid bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch dioxygenase activitysearch oxidoreductase activitysearch protein complexsearch endoplasmic reticulumsearch organelle membranesearch intracellular membrane-bounded organellesearch neuron projectionsearch cytoplasmsearch endoplasmic reticulum membranesearch membranesearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search