5ca2 Summary



The structure was published by Krebs, J.F., Fierke, C.A., Alexander, R.S., and Christianson, D.W., in 1991 in a paper entitled "Conformational mobility of His-64 in the Thr-200----Ser mutant of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) membranesearch basolateral plasma membranesearch cytoplasmsearch extracellular spacesearch cytosolsearch apical part of cellsearch plasma membranesearch extracellular vesicular exosomesearch microvillussearch axonsearch myelin sheathsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch positive regulation of cellular pH reductionsearch small molecule metabolic processsearch response to organic substancesearch response to steroid hormonesearch bicarbonate transportsearch response to pHsearch angiotensin-activated signaling pathwaysearch regulation of anion transportsearch regulation of intracellular pHsearch one-carbon metabolic processsearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch positive regulation of osteoclast differentiationsearch response to estrogensearch regulation of chloride transportsearch positive regulation of bone resorptionsearch morphogenesis of an epitheliumsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch