5c97

X-ray diffraction
3.37Å resolution

Function and Biology Details

Reaction catalysed:
Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-193794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Leucyl-cystinyl aminopeptidase, pregnancy serum form Chains: A, B
Molecule details ›
Chains: A, B
Length: 912 amino acids
Theoretical weight: 104.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UIQ6 (Residues: 111-111, 155-1025; Coverage: 85%)
Gene names: LNPEP, OTASE
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 69Å b: 260.151Å c: 73.36Å
α: 90° β: 111.61° γ: 90°
R-values:
R R work R free
0.22 0.216 0.285
Expression system: Homo sapiens