› 5b7v

X-ray diffraction
2.15Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 310 amino acids
Theoretical weight: 35.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11362 (Residues: 456-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand LWJ 2 x LWJ
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 211.21Å b: 56.75Å c: 65.45Å
α: 90° β: 107.43° γ: 90°
R-values:
R R work R free
0.224 0.223 0.256
Expression system: Spodoptera frugiperda

Quick links

Citations

25 review citations

Advances and challenges in targeting FGFR signalling in cancer.
Babina et al. (2017)
24 more

5 mentions without citation

Fibroblast growth factor receptor fusions in cancer: opportunities and challenges.
Chen et al. (2021)
4 more