› 5ain

X-ray diffraction
2.3Å resolution

Varenicline Interactions at the 5HT3 Receptor Ligand Binding Site are Revealed by 5HTBP

Released:
DOI: 10.2210/pdb5ain/pdb
PDB entry 5ain coloured by chain, front view.
PDB entry 5ain coloured by chain, side view.
PDB entry 5ain coloured by chain, top view.
Source organism: Aplysia californica
Primary publication:
Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP.
Price KL, Lillestol RK, Ulens C, Lummis SC
ACS Chem Neurosci 6 1151-7 (2015)
PMID: 25648658

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186694 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 212 amino acids
Theoretical weight: 24.1 KDa
Source organism: Aplysia californica
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WSF8 (Residues: 20-231; Coverage: 98%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

1 bound ligand:
Ligand QMR 5 x QMR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P41212
Unit cell:
a: 72.794Å b: 72.794Å c: 479.221Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.162 0.224
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery.
Wu et al. (2015)
1 more

9 mentions without citation

Investigation of the Biological Activities and Characterization of Bioactive Constituents of Ophiorrhiza rugosa var. prostrata (D.Don) & Mondal Leaves through In Vivo, In Vitro, and In Silico Approaches.
Adnan et al. (2019)
8 more