› 5aef

Electron Microscopy
5Å resolution

Electron cryo-microscopy of an Abeta(1-42)amyloid fibril

Released:
DOI: 10.2210/pdb5aef/pdb
PDB entry 5aef coloured by chain, front view.
PDB entry 5aef coloured by chain, side view.
PDB entry 5aef coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.
Schmidt M, Rohou A, Lasker K, Yadav JK, Schiene-Fischer C, Fändrich M, Grigorieff N
Proc Natl Acad Sci U S A 112 11858-63 (2015)
PMID: 26351699
Related structures: EMD-3132

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(42) Chains: A, B
Molecule details ›
Chains: A, B
Length: 28 amino acids
Theoretical weight: 2.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 686-713; Coverage: 4%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5Å
Relevant EMDB volumes: EMD-3132
Expression system: Not provided

Quick links

Citations

25 review citations

The activities of amyloids from a structural perspective.
Riek et al. (2016)
24 more

10 mentions without citation

Amyloid fibril polymorphism: a challenge for molecular imaging and therapy.
Fändrich et al. (2018)
9 more