› 5uez

X-ray diffraction
1.51Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: O60885 (Residues: 352-457; Coverage: 8%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 89G 1 x 89G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21212
Unit cell:
a: 57.982Å b: 72.782Å c: 33.654Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.204
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4

Quick links

Citations

5 review citations

Targeting Brd4 for cancer therapy: inhibitors and degraders.
Duan et al. (2018)
4 more

2 mentions without citation

PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition.
Wang et al. (2020)
1 more