› 5t0p

X-ray diffraction
2.5Å resolution

c-Src kinase domain in complex with Rao-IV-151

Released:
DOI: 10.2210/pdb5t0p/pdb
PDB entry 5t0p coloured by chain, front view.
PDB entry 5t0p coloured by chain, side view.
PDB entry 5t0p coloured by chain, top view.
Source organism: Gallus gallus
Entry authors: Dieter EM, Merritt EA, Maly DJ

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 73A 2 x 73A
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P1
Unit cell:
a: 41.675Å b: 63.922Å c: 74.994Å
α: 102.08° β: 90.36° γ: 90.14°
R-values:
R R work R free
0.267 0.264 0.323
Expression system: Escherichia coli

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