› 5qc7

X-ray diffraction
1.9Å resolution

Crystal structure of human Cathepsin-S with bound ligand

Released:
DOI: 10.2210/pdb5qc7/pdb
PDB entry 5qc7 coloured by chain, front view.
PDB entry 5qc7 coloured by chain, side view.
PDB entry 5qc7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bembenek SD, Ameriks MK, Mirzadegan T, Yang H, Shao C, Burley SK

Function and Biology Details

Reaction catalysed: 
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|- compound.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150575 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin S Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 24.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P25774 (Residues: 114-331; Coverage: 69%)
Gene name: CTSS
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

3 bound ligands:
Ligand BQS 2 x BQS
Ligand EOH 5 x EOH
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 36.97Å b: 58.5Å c: 59.54Å
α: 66.28° β: 69.76° γ: 72.62°
R-values:
R R work R free
0.158 0.155 0.204
Expression system: Spodoptera frugiperda

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