› 5nwu

Solution NMR

NMR assignment and structure of a peptide derived from the fusion peptide of HIV-1 gp41 in the presence of hexafluoroisopropanol

Released:
DOI: 10.2210/pdb5nwu/pdb
PDB entry 5nwu coloured by chain, ensemble of 20 models, front view.
PDB entry 5nwu coloured by chain, ensemble of 20 models, side view.
PDB entry 5nwu coloured by chain, ensemble of 20 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structure-Related Roles for the Conservation of the HIV-1 Fusion Peptide Sequence Revealed by Nuclear Magnetic Resonance.
Serrano S, Huarte N, Rujas E, Andreu D, Nieva JL, Jiménez MA
Biochemistry 56 5503-5511 (2017)
PMID: 28930470

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.82 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 514-528, 655-671; Coverage: 4%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Mechanistic insights of host cell fusion of SARS-CoV-1 and SARS-CoV-2 from atomic resolution structure and membrane dynamics.
Chakraborty et al. (2020)
1 more