› 5m33

X-ray diffraction
1.28Å resolution

Structural tuning of CD81LEL (space group P21)

Released:
DOI: 10.2210/pdb5m33/pdb
PDB entry 5m33 coloured by chain, front view.
PDB entry 5m33 coloured by chain, side view.
PDB entry 5m33 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop.
Cunha ES, Sfriso P, Rojas AL, Roversi P, Hospital A, Orozco M, Abrescia NGA
Structure 25 53-65 (2017)
PMID: 27916518

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157955 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD81 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P60033 (Residues: 113-201; Coverage: 38%)
Gene names: CD81, TAPA1, TSPAN28
Sequence domains: Tetraspanin family
Structure domains: Tetraspanin

Ligands and Environments

1 bound ligand:
Ligand EDO 7 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 31.445Å b: 75.846Å c: 37.363Å
α: 90° β: 107.12° γ: 90°
R-values:
R R work R free
0.138 0.136 0.173
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2.
Ströh et al. (2018)
2 more

1 mention without citation

Structural insights into hepatitis C virus receptor binding and entry.
Kumar et al. (2021)