› 5li1

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154424 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein kinase C iota type Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41743 (Residues: 248-596; Coverage: 59%)
Gene names: DXS1179E, PRKCI
Sequence domains:
PDZ domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.39 KDa
Source organism: Xenopus tropicalis
Expression system: synthetic construct
UniProt:
  • Canonical: Q28E03 (Residues: 271-290; Coverage: 4%)
Gene names: TEgg053l09.1-001, pard3

Ligands and Environments

4 bound ligands:
Ligand ANP 1 x ANP
Ligand GOL 1 x GOL
Ligand K 1 x K
Ligand MG 2 x MG
2 modified residues:
Ligand TPO 2 x TPO
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 82.03Å b: 82.03Å c: 90.79Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.154 0.15 0.217
Expression systems:
  • Spodoptera frugiperda
  • synthetic construct

Quick links

Citations

12 review citations

Protein kinase C: perfectly balanced.
Newton AC. (2018)
11 more

3 mentions without citation

Par-3 family proteins in cell polarity & adhesion.
Thompson BJ. (2022)
2 more