› 5l1b

X-ray diffraction
4Å resolution

AMPA subtype ionotropic glutamate receptor GluA2 in Apo state

Released:
DOI: 10.2210/pdb5l1b/pdb
PDB entry 5l1b coloured by chain, front view.
PDB entry 5l1b coloured by chain, side view.
PDB entry 5l1b coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.
Yelshanskaya MV, Singh AK, Sampson JM, Narangoda C, Kurnikova M, Sobolevsky AI
Neuron 91 1305-1315 (2016)
PMID: 27618672

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 803 amino acids
Theoretical weight: 89.81 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-565, 588-847; Coverage: 92%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 92.051Å b: 309.391Å c: 110.021Å
α: 90° β: 93.77° γ: 90°
R-values:
R R work R free
0.266 0.265 0.292
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins.
Greger et al. (2017)
8 more

12 mentions without citation

Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.
Yelshanskaya et al. (2016)
11 more