› 5kls

X-ray diffraction
3.3Å resolution

Structure of CavAb in complex with Br-dihydropyridine derivative UK-59811

Released:
DOI: 10.2210/pdb5kls/pdb
PDB entry 5kls coloured by chain, front view.
PDB entry 5kls coloured by chain, side view.
PDB entry 5kls coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs.
Tang L, Gamal El-Din TM, Swanson TM, Pryde DC, Scheuer T, Zheng N, Catterall WA
Nature 537 117-121 (2016)
PMID: 27556947

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 33.11 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-267; Coverage: 100%)
Gene name: Abu_1752
Sequence domains: Ion transport protein

Ligands and Environments

3 bound ligands:
Ligand MC3 15 x MC3
Ligand CA 2 x CA
Ligand 6UC 1 x 6UC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Unit cell:
a: 125.47Å b: 125.87Å c: 191.705Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.276 0.274 0.3
Expression system: Trichoplusia ni

Quick links

Citations

25 review citations

Discovery and Development of Calcium Channel Blockers.
Godfraind T. (2017)
24 more

3 mentions without citation

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.
Enkavi et al. (2019)
2 more