› 5jkg

X-ray diffraction
2.35Å resolution

The crystal structure of FGFR4 kinase domain in complex with LY2874455

Released:
DOI: 10.2210/pdb5jkg/pdb
PDB entry 5jkg coloured by chain, front view.
PDB entry 5jkg coloured by chain, side view.
PDB entry 5jkg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455.
Wu D, Guo M, Philips MA, Qu L, Jiang L, Li J, Chen X, Chen Z, Chen L, Chen Y
PLoS One 11 e0162491 (2016)
PMID: 27618313

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149636 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P22455 (Residues: 445-753; Coverage: 40%)
Gene names: FGFR4, JTK2, TKF
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 6LF 1 x 6LF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 61.887Å b: 61.887Å c: 186.059Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.233 0.277
Expression system: Escherichia coli BL21

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Citations

3 review citations

Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance.
Krook et al. (2021)
2 more

7 mentions without citation

Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors.
Dai et al. (2019)
6 more