› 5iug

X-ray diffraction
1.93Å resolution

Crystal Structure of Anaplastic Lymphoma Kinase (ALK) in complex with 5a

Released:
DOI: 10.2210/pdb5iug/pdb
PDB entry 5iug coloured by chain, front view.
PDB entry 5iug coloured by chain, side view.
PDB entry 5iug coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).
Tu CH, Lin WH, Peng YH, Hsu T, Wu JS, Chang CY, Lu CT, Lyu PC, Shih C, Jiaang WT, Wu SY
J Med Chem 59 3906-19 (2016)
PMID: 27031565

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALK tyrosine kinase receptor Chain: A
Molecule details ›
Chain: A
Length: 327 amino acids
Theoretical weight: 36.83 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UM73 (Residues: 1084-1410; Coverage: 20%)
Gene name: ALK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 729 1 x 729
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P212121
Unit cell:
a: 51.913Å b: 56.495Å c: 102.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.211
Expression system: Spodoptera frugiperda

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Citations

2 review citations

Novel targeted therapies of T cell lymphomas.
Iżykowska et al. (2020)
1 more