› 5if5

X-ray diffraction
2.25Å resolution

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol

Released:
DOI: 10.2210/pdb5if5/pdb
PDB entry 5if5 coloured by chain, front view.
PDB entry 5if5 coloured by chain, side view.
PDB entry 5if5 coloured by chain, top view.
Source organism: Influenza A virus (A/Wilson-Smith/1933(H1N1))
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-147419 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase acidic protein Chain: A
Molecule details ›
Chain: A
Length: 464 amino acids
Theoretical weight: 53.1 KDa
Source organism: Influenza A virus (A/Wilson-Smith/1933(H1N1))
Expression system: Escherichia coli
UniProt:
  • Canonical: P15659 (Residues: 254-716; Coverage: 65%)
Gene name: PA
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA

Ligands and Environments

3 bound ligands:
Ligand DMS 1 x DMS
Ligand EDO 3 x EDO
Ligand 6B0 1 x 6B0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P6522
Unit cell:
a: 68.43Å b: 68.43Å c: 395.68Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.176 0.208
Expression system: Escherichia coli

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