› 5hz5

X-ray diffraction
1.4Å resolution

FABP5 in complex with 6-Chloro-4-phenyl-2-piperidin-1-yl-3-(1H-tetrazol-5-yl)-quinoline

Released:
DOI: 10.2210/pdb5hz5/pdb
PDB entry 5hz5 coloured by chain, front view.
PDB entry 5hz5 coloured by chain, side view.
PDB entry 5hz5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.
Kühne H, Obst-Sander U, Kuhn B, Conte A, Ceccarelli SM, Neidhart W, Rudolph MG, Ottaviani G, Gasser R, So SS, Li S, Zhang X, Gao L, Myers M
Bioorg Med Chem Lett 26 5092-5097 (2016)
PMID: 27658368

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169567 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein 5 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01469 (Residues: 2-135; Coverage: 99%)
Gene name: FABP5
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand DMS 1 x DMS
Ligand SO4 1 x SO4
Ligand 65X 1 x 65X
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 62.79Å b: 62.79Å c: 75.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.208 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.
Floresta et al. (2017)
1 other article

2 mentions without citation

Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells.
Sun et al. (2017)
1 more