› 5hfs

X-ray diffraction
1.97Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161163 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gingipain R2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 72 amino acids
Theoretical weight: 7.76 KDa
Source organism: Porphyromonas gingivalis
Expression system: Escherichia coli
UniProt:
  • Canonical: P95493 (Residues: 665-736; Coverage: 10%)
Gene names: PG_0506, prtRII, rgp2, rgpB
Sequence domains: Peptidase M60 C-terminal domain

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand ZN 5 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P65
Unit cell:
a: 37.69Å b: 37.69Å c: 184.15Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.219 0.247
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function.
Lasica et al. (2017)
6 more

2 mentions without citation

The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain.
de Diego et al. (2016)
1 more