Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
ATP + H(2)O = ADP + phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
3C-like serine proteinase (preferred)
PDBe Complex ID:
PDB-CPX-148744 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridylate-specific endoribonuclease nsp11
Molecule details ›
Chains: A, B, C, D, E, F
Length: 221 amino acids
Theoretical weight: 24.36 KDa
Source organism: Equine arteritis virus Bucyrus
Expression system: Escherichia coli
UniProt:
Sequence domains: Coronavirus replicase NSP15, uridylate-specific endoribonuclease
Length: 221 amino acids
Theoretical weight: 24.36 KDa
Source organism: Equine arteritis virus Bucyrus
Expression system: Escherichia coli
UniProt:
- Canonical:
P19811 (Residues: 2838-3056; Coverage: 7%)
Sequence domains: Coronavirus replicase NSP15, uridylate-specific endoribonuclease
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL17U
Spacegroup:
R32
Expression system: Escherichia coli
