5fwy

X-ray diffraction
2.12Å resolution

Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-148605 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 385 amino acids
Theoretical weight: 43.73 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-400; Coverage: 44%)
Gene names: GluA2, Glur2, Gria2
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold
Glutamate receptor 3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 390 amino acids
Theoretical weight: 45.09 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19492 (Residues: 23-403; Coverage: 44%)
Gene names: GluA3, Glur3, Gria3
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P1
Unit cell:
a: 66.27Å b: 78.519Å c: 107.85Å
α: 83.36° β: 87.4° γ: 64.94°
R-values:
R R work R free
0.194 0.192 0.231
Expression system: Homo sapiens