› 5fti

X-ray diffraction
1.35Å resolution

Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form)

Released:
DOI: 10.2210/pdb5fti/pdb
PDB entry 5fti coloured by chain, front view.
PDB entry 5fti coloured by chain, side view.
PDB entry 5fti coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.
Dawe GB, Musgaard M, Aurousseau MRP, Nayeem N, Green T, Biggin PC, Bowie D
Neuron 89 1264-1276 (2016)
PMID: 26924438

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 291 amino acids
Theoretical weight: 32.26 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P19491 (Residues: 404-527, 653-796; Coverage: 31%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand GLU 2 x GLU
Ligand LI 2 x LI
Ligand SO4 4 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P2
Unit cell:
a: 67.316Å b: 47.562Å c: 96.754Å
α: 90° β: 95.65° γ: 90°
R-values:
R R work R free
0.162 0.161 0.178
Expression system: Escherichia coli BL21

Quick links

Citations

10 review citations

Molecular Dynamics Simulation for All.
Hollingsworth et al. (2018)
9 more