5eq0

X-ray diffraction
1.18Å resolution

Crystal Structure of chromodomain of CBX8 in complex with inhibitor UNC3866

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-165611 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chromobox protein homolog 8 Chain: A
Molecule details ›
Chain: A
Length: 55 amino acids
Theoretical weight: 6.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HC52 (Residues: 7-61; Coverage: 14%)
Gene names: CBX8, PC3, RC1
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
unc3866 Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 795 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 30.575Å b: 30.007Å c: 36.104Å
α: 90° β: 100.17° γ: 90°
R-values:
R R work R free
0.158 0.156 0.186
Expression systems:
  • Escherichia coli
  • Not provided