› 5eod

X-ray diffraction
3.1Å resolution

Human Plasma Coagulation FXI with peptide LP2

Released:
DOI: 10.2210/pdb5eod/pdb
PDB entry 5eod coloured by chain, front view.
PDB entry 5eod coloured by chain, side view.
PDB entry 5eod coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Wong SS, Østergaard S, Hall G, Li C, Williams PM, Stennicke H, Emsley J
Blood 127 2915-23 (2016)
PMID: 27006387

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137282 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor XI Chain: A
Molecule details ›
Chain: A
Length: 606 amino acids
Theoretical weight: 67.99 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P03951 (Residues: 20-625; Coverage: 100%)
Gene name: F11
Sequence domains:
Structure domains:
LP2 Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 751 Da
Source organism: Homo sapiens
Expression system: synthetic construct

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P43212
Unit cell:
a: 81.065Å b: 81.065Å c: 253.084Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.189 0.274
Expression systems:
  • Cricetulus griseus
  • synthetic construct

Quick links

Citations

2 review citations

An update on factor XI structure and function.
Mohammed et al. (2018)
1 more

1 mention without citation

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Wong et al. (2016)