› 5dyh

X-ray diffraction
2.68Å resolution

Ti(IV) bound human serum transferrin

Released:
DOI: 10.2210/pdb5dyh/pdb
PDB entry 5dyh coloured by chain, front view.
PDB entry 5dyh coloured by chain, side view.
PDB entry 5dyh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unusual Synergism of Transferrin and Citrate in the Regulation of Ti(IV) Speciation, Transport, and Toxicity.
Tinoco AD, Saxena M, Sharma S, Noinaj N, Delgado Y, Quiñones González EP, Conklin SE, Zambrana N, Loza-Rosas SA, Parks TB
J Am Chem Soc 138 5659-65 (2016)
PMID: 27070073

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chains: A, B
Molecule details ›
Chains: A, B
Length: 698 amino acids
Theoretical weight: 77.17 KDa
Source organism: Homo sapiens
Expression system: Oryza sativa
UniProt:
  • Canonical: P02787 (Residues: 1-698; Coverage: 100%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand CIT 11 x CIT
Ligand 4TI 2 x 4TI
Ligand CO3 2 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 88.275Å b: 102.016Å c: 197.899Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.237
Expression system: Oryza sativa

Quick links

Citations

6 review citations

Binary titanium alloys as dental implant materials-a review.
Liu et al. (2017)
5 more

4 mentions without citation

Using X-ray Diffraction Techniques for Biomimetic Drug Development, Formulation, and Polymorphic Characterization.
Rodríguez et al. (2020)
3 more