› 5cka

X-ray diffraction
1.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158314 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand GOL 2 x GOL
Ligand ACT 2 x ACT
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 76.98Å b: 28.91Å c: 57.32Å
α: 90° β: 128.57° γ: 90°
R-values:
R R work R free
0.181 0.176 0.226
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Third generation antibody discovery methods: in silico rational design.
Sormanni et al. (2018)
3 more

1 mention without citation

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
Camilloni et al. (2016)