› 5ccs

X-ray diffraction
2.1Å resolution

Human Cyclophilin D Complexed with Inhibitor

Released:
DOI: 10.2210/pdb5ccs/pdb
PDB entry 5ccs coloured by chain, front view.
PDB entry 5ccs coloured by chain, side view.
PDB entry 5ccs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gibson RP, Shore E, Kershaw N, Awais M, Javed A, Latawiec D, Pandalaneni S, Wen L, Berry N, O'Neill P, Sutton R, Lian LY

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase F, mitochondrial Chain: X
Molecule details ›
Chain: X
Length: 165 amino acids
Theoretical weight: 17.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30405 (Residues: 44-207; Coverage: 79%)
Gene names: CYP3, PPIF
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

1 bound ligand:
Ligand C4Y 1 x C4Y
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 37.27Å b: 58.7Å c: 77.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.16 0.196
Expression system: Escherichia coli BL21(DE3)

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