› 5c30

X-ray diffraction
1.55Å resolution

Crystal Structure of Rabbit Ryanodine Receptor 1 Repeat12 Domain

Released:
DOI: 10.2210/pdb5c30/pdb
PDB entry 5c30 coloured by chain, front view.
PDB entry 5c30 coloured by chain, side view.
PDB entry 5c30 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.
Yuchi Z, Yuen SM, Lau K, Underhill AQ, Cornea RL, Fessenden JD, Van Petegem F
Nat Commun 6 7947 (2015)
PMID: 26245150

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 22.92 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11716 (Residues: 857-1054; Coverage: 4%)
Gene name: RYR1
Sequence domains: RyR domain

Ligands and Environments

1 bound ligand:
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P3121
Unit cell:
a: 94.44Å b: 94.44Å c: 67.22Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.15 0.149 0.164
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

The structural basis of ryanodine receptor ion channel function.
Meissner G. (2017)
10 more

7 mentions without citation

Cryo-electron microscopy and X-ray crystallography: complementary approaches to structural biology and drug discovery.
Vénien-Bryan et al. (2017)
6 more