› 5bt5

X-ray diffraction
1.4Å resolution

Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe

Released:
DOI: 10.2210/pdb5bt5/pdb
PDB entry 5bt5 coloured by chain, front view.
PDB entry 5bt5 coloured by chain, side view.
PDB entry 5bt5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Hay D, Krojer T, Nunez-Alonso G, Picaud S, Newman JA, Fedorov O, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Brennan PE, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 13.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25440 (Residues: 344-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand EDO 4 x EDO
Ligand 2LO 1 x 2LO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 52.761Å b: 71.806Å c: 31.996Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.16 0.182
Expression system: Escherichia coli BL21(DE3)

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