› 5ag2

X-ray diffraction
1.77Å resolution

SOD-3 azide complex

Released:
DOI: 10.2210/pdb5ag2/pdb
PDB entry 5ag2 coloured by chain, front view.
PDB entry 5ag2 coloured by chain, side view.
PDB entry 5ag2 coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
The structure of the Caenorhabditis elegans manganese superoxide dismutase MnSOD-3-azide complex.
Hunter GJ, Trinh CH, Bonetta R, Stewart EE, Cabelli DE, Hunter T
Protein Sci 24 1777-88 (2015)
PMID: 26257399

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Mn] 2, mitochondrial Chains: A, C
Molecule details ›
Chains: A, C
Length: 195 amino acids
Theoretical weight: 22.41 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: P41977 (Residues: 25-218; Coverage: 89%)
Gene names: C08A9.1, sod-3
Sequence domains:
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand MN 2 x MN
Ligand AZI 2 x AZI
Ligand ACT 1 x ACT
Ligand MLI 1 x MLI
Ligand SO4 1 x SO4
1 modified residue:
Ligand OCS 2 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P41212
Unit cell:
a: 82.06Å b: 82.06Å c: 137.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.216
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Potential Therapeutic Applications of MnSODs and SOD-Mimetics.
Bonetta R. (2018)
1 more

4 mentions without citation

A Review of the Catalytic Mechanism of Human Manganese Superoxide Dismutase.
Azadmanesh et al. (2018)
3 more