› 5a4h

Solution NMR

Solution structure of the lipid droplet anchoring peptide of CGI-58 bound to DPC micelles

Released:
DOI: 10.2210/pdb5a4h/pdb
PDB entry 5a4h coloured by chain, ensemble of 20 models, front view.
PDB entry 5a4h coloured by chain, ensemble of 20 models, side view.
PDB entry 5a4h coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structure of a CGI-58 Motif Provides the Molecular Basis of Lipid Droplet Anchoring.
Boeszoermenyi A, Nagy HM, Arthanari H, Pillip CJ, Lindermuth H, Luna RE, Wagner G, Zechner R, Zangger K, Oberer M
J. Biol. Chem. 290 26361-72 (2015)
PMID: 26350461

Function and Biology Details

Reaction catalysed: 
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190091 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 3.98 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9DBL9 (Residues: 10-43; Coverage: 10%)
Gene name: Abhd5

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 40%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.
Kory et al. (2016)
13 more

2 mentions without citation

Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring.
Boeszoermenyi et al. (2015)
1 more