Function and Biology Details
Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Mitogen-activated protein (MAP) kinase, JNK
- Mitogen-activated protein (MAP) kinase phosphatase
- Dual specificity protein phosphatase domain
- Protein-tyrosine phosphatase-like
- Protein-tyrosine phosphatase, active site
- Tyrosine-specific protein phosphatases domain
- Dual specificity phosphatase, catalytic domain
- Serine/threonine-protein kinase, active site
3 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155385 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 8
Molecule details ›
Chains: A, C, E, F
Length: 371 amino acids
Theoretical weight: 42.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Protein kinase domain
Structure domains:
Length: 371 amino acids
Theoretical weight: 42.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P45983 (Residues: 1-363; Coverage: 85%)
Sequence domains: Protein kinase domain
Structure domains:
Dual specificity protein phosphatase 16
Molecule details ›
Chains: B, D, G, H
Length: 167 amino acids
Theoretical weight: 18.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily
Length: 167 amino acids
Theoretical weight: 18.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9BY84 (Residues: 156-301; Coverage: 22%)
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily
