› 4ycm

X-ray diffraction
3.2Å resolution

Crystal structure of the calcium pump with bound marine macrolide BLS

Released:
DOI: 10.2210/pdb4ycm/pdb
PDB entry 4ycm coloured by chain, front view.
PDB entry 4ycm coloured by chain, side view.
PDB entry 4ycm coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding.
Morita M, Ogawa H, Ohno O, Yamori T, Suenaga K, Toyoshima C
FEBS Lett 589 1406-11 (2015)
PMID: 25957767

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

4 bound ligands:
Ligand NA 1 x NA
Ligand SO4 2 x SO4
Ligand 7BS 1 x 7BS
Ligand PTY 2 x PTY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P41212
Unit cell:
a: 71.666Å b: 71.666Å c: 585.235Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.215 0.26

Quick links

Citations

2 review citations

Biomaterials from the sea: Future building blocks for biomedical applications.
Wan et al. (2021)
1 more

2 mentions without citation

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
Aguayo-Ortiz et al. (2020)
1 more