4xim Summary

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PROTEIN ENGINEERING OF XYLOSE (GLUCOSE) ISOMERASE FROM ACTINOPLANES MISSOURIENSIS. 1. CRYSTALLOGRAPHY AND SITE-DIRECTED MUTAGENESIS OF METAL BINDING SITES

The structure was published by Jenkins, J., Janin, J., Rey, F., et al., Stanssens, P., Matthyssens, G., and Lambeir, A.M., in 1992 in a paper entitled "Protein engineering of xylose (glucose) isomerase from Actinoplanes missouriensis. 1. Crystallography and site-directed mutagenesis of metal binding sites." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of D-XYLOSE ISOMERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A D-XYLOSE ISOMERASE P12851 (2-394) (XYLA_ACTM4)search Actinoplanes missouriensis 431search 100% 393 99%
B D-XYLOSE ISOMERASE P12851 (2-394) (XYLA_ACTM4)search Actinoplanes missouriensis 431search 100% 393 99%
C D-XYLOSE ISOMERASE P12851 (2-394) (XYLA_ACTM4)search Actinoplanes missouriensis 431search 100% 393 99%
D D-XYLOSE ISOMERASE P12851 (2-394) (XYLA_ACTM4)search Actinoplanes missouriensis 431search 100% 393 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12851 (2 - 394) D-XYLOSE ISOMERASE Actinoplanes missouriensis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P12851) Xylose isomerasesearch Divalent-metal-dependent TIM barrel enzymessearch PF01261: Xylose isomerase-like TIM barrelsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (P12851) D-xylose metabolic processsearch pentose-phosphate shuntsearch carbohydrate metabolic processsearch xylose isomerase activitysearch isomerase activitysearch metal ion bindingsearch magnesium ion bindingsearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D Xylose isomerasesearch Xylose isomerase-like, TIM barrel domainsearch Xylose isomerase, actinobacteriasearch