Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
GTP + a 5'-diphospho-[mRNA] = diphosphate + a 5'-(5'-triphosphoguanosine)-[mRNA]
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Ubiquitin domain
- Ubiquitin-like domain
- Peptidase C16, coronavirus
- Ubiquitin conserved site
- Ubiquitin-like domain superfamily
- Papain-like viral protease, palm and finger domains, coronavirus
- Papain-like protease, thumb domain superfamily, coronavirus
- NSP3, second ubiquitin-like (Ubl) domain, coronavirus
1 more domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125703 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Papain-like proteinase nsp3
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 36.16 KDa
Source organism: Betacoronavirus England 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Coronavirus papain-like peptidase
Structure domains:
Length: 326 amino acids
Theoretical weight: 36.16 KDa
Source organism: Betacoronavirus England 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
K9N7C7 (Residues: 1482-1801; Coverage: 5%)
Sequence domains: Coronavirus papain-like peptidase
Structure domains:
Ubiquitin
Molecule details ›
Chain: B
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P0CG47 (Residues: 153-228; Coverage: 33%)
Sequence domains: Ubiquitin family
