4v4e Summary

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PDB entry 4v4e (supersedes 1ti6,1vlf)

Crystal Structure of Pyrogallol-Phloroglucinol Transhydroxylase from Pelobacter acidigallici complexed with inhibitor 1,2,4,5-tetrahydroxy-benzene

The structure was published by Messerschmidt, A., Niessen, H., Abt, D., Einsle, O., Schink, B., and Kroneck, P.M.H., in 2004 in a paper entitled "Crystal structure of pyrogallol-phloroglucinol transhydroxylase, an Mo enzyme capable of intermolecular hydroxyl transfer between phenols" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Pyrogallol hydroxytransferase large subunit and Pyrogallol hydroxytransferase small subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
C Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
E Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
G Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
I Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
K Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
M Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
O Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
Q Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
S Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
U Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
W Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
B Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
D Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
F Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
H Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
J Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
L Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
N Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
P Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
R Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
T Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
V Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
X Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P80563 (1 - 875) Pyrogallol hydroxytransferase large subunit Pelobacter acidigallici
P80564 (1 - 274) Pyrogallol hydroxytransferase small subunit Pelobacter acidigallici

Chain Sequence family (Pfam)
A, C, E, G, I, K, M, O, Q, S, U, W Molybdopterin oxidoreductasesearch, Molydopterin dinucleotide binding domainsearch
B, D, F, H, J, L, N, P, R, T, V, X Cna protein B-type domainsearch, 4Fe-4S dicluster domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, C, E, G, I, K, M, O, Q, S, U, W (P80563) oxidoreductase activitysearch pyrogallol hydroxytransferase activitysearch molybdenum ion bindingsearch metal ion bindingsearch oxidation-reduction processsearch
B, D, F, H, J, L, N, P, R, T, V, X (P80564) oxidoreductase activitysearch pyrogallol hydroxytransferase activitysearch metal ion bindingsearch iron-sulfur cluster bindingsearch 4 iron, 4 sulfur cluster bindingsearch oxidation-reduction processsearch