› 4uy9

X-ray diffraction
2.81Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 323 amino acids
Theoretical weight: 36.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P80192 (Residues: 135-456; Coverage: 29%)
Gene names: MAP3K9, MLK1, PRKE1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P6122
Unit cell:
a: 96.93Å b: 96.93Å c: 416.95Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.228
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Orange is the new black: Kinases are the new master regulators of tumor suppression.
An et al. (2019)
13 other articles

2 mentions without citation

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.
Marusiak et al. (2016)
1 more