› 4uuw

X-ray diffraction
1.98Å resolution

Competence or damage-inducible protein CinA from Thermus thermophilus

Released:
DOI: 10.2210/pdb4uuw/pdb
PDB entry 4uuw coloured by chain, front view.
PDB entry 4uuw coloured by chain, side view.
PDB entry 4uuw coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Primary publication:
Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus.
Karuppiah V, Thistlethwaite A, Dajani R, Warwicker J, Derrick JP
J Biol Chem 289 33187-97 (2014)
PMID: 25313401

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CinA-like protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 394 amino acids
Theoretical weight: 43.04 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q5SHB0 (Residues: 1-394; Coverage: 100%)
Gene name: TTHA1820
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand AMP 1 x AMP
Ligand MG 2 x MG
Ligand SO4 2 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 73.28Å b: 93.71Å c: 132.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.224
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Pyrazinamide: the importance of uncovering the mechanisms of action in mycobacteria.
Stehr et al. (2015)
1 more

2 mentions without citation

Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus.
Karuppiah et al. (2014)
1 more