› 4uf9

Electron Microscopy
10.3Å resolution

Electron cryo-microscopy structure of PB1-p62 type T filaments

Released:
DOI: 10.2210/pdb4uf9/pdb
PDB entry 4uf9 coloured by chain, front view.
PDB entry 4uf9 coloured by chain, side view.
PDB entry 4uf9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The selective autophagy receptor p62 forms a flexible filamentous helical scaffold.
Ciuffa R, Lamark T, Tarafder AK, Guesdon A, Rybina S, Hagen WJ, Johansen T, Sachse C
Cell Rep 11 748-58 (2015)
PMID: 25921531
Related structures: EMD-2937

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sequestosome-1 Chains: A, B, D
Molecule details ›
Chains: A, B, D
Length: 122 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q13501 (Residues: 1-122; Coverage: 28%)
Gene names: ORCA, OSIL, SQSTM1
Sequence domains: PB1 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 10.3Å
Relevant EMDB volumes: EMD-2937
Expression system: Escherichia coli BL21

Quick links

Citations

40 review citations

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.
Katsuragi et al. (2015)
39 more

2 mentions without citation

Structure biology of selective autophagy receptors.
Kim et al. (2016)
1 more