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UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE

Source organism: Escherichia coli
Biochemical function: identical protein binding
Biological process: cell wall organization
Cellular component: cytoplasm

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EC 6.3.2.9: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase

Reaction catalysed:
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
Systematic name:
UDP-N-acetyl-alpha-D-muramoyl-L-alanine:D-glutamate ligase (ADP-forming)
Alternative Name(s):
  • D-glutamate ligase
  • D-glutamate-adding enzyme
  • MurD synthetase
  • UDP-Mur-NAC-L-Ala:D-Glu ligase
  • UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (ADP-forming)
  • UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)
  • UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
  • UDP-N-acetylmuramoylalanine--D-glutamate ligase
  • Uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02875
Domain description: Mur ligase family, glutamate ligase domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of Pfam domain PF02875 (Mur ligase family, glutamate ligase domain) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.

PF08245
Domain description: Mur ligase middle domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of Pfam domain PF08245 (Mur ligase middle domain) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.

PF21799
Domain description: Mur ligase MurD-like, N-terminal domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of Pfam domain PF21799 (Mur ligase MurD-like, N-terminal domain) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005762
Domain description: UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
IPR036615
Domain description: Mur ligase, C-terminal domain superfamily
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
IPR036565
Domain description: Mur-like, catalytic domain superfamily
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
IPR004101
Domain description: Mur ligase, C-terminal
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
IPR013221
Domain description: Mur ligase, central
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase

Structure domains

CATH CATH domains
3.90.190.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Protein-Tyrosine Phosphatase; Chain A
Homology: Mur ligase, C-terminal domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of CATH domain 3.90.190.20 (Protein-Tyrosine Phosphatase; Chain A) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.
3.40.1190.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
Homology: Mur-like, catalytic domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of CATH domain 3.40.1190.10 (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.
SCOP SCOP annotations
53245
Class: Alpha and beta proteins (a/b)
Fold: MurD-like peptide ligases, peptide-binding domain
Superfamily: MurD-like peptide ligases, peptide-binding domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of SCOP domain 53245 (MurCDEF C-terminal domain) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.
53624
Class: Alpha and beta proteins (a/b)
Fold: Ribokinase-like
Superfamily: MurD-like peptide ligases, catalytic domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of SCOP domain 53624 (MurCDEF) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.
51985
Class: Alpha and beta proteins (a/b)
Fold: MurCD N-terminal domain
Superfamily: MurCD N-terminal domain
Occurring in:
  1. UDP-N-acetylmuramoylalanine--D-glutamate ligase
The deposited structure of PDB entry 4uag contains 1 copy of SCOP domain 51985 (MurCD N-terminal domain) in UDP-N-acetylmuramoylalanine--D-glutamate ligase. Showing 1 copy in chain A.

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