4tsv Summary

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HIGH RESOLUTION CRYSTAL STRUCTURE OF A HUMAN TNF-ALPHA MUTANT

The structure was published by Cha, S.S., Kim, J.S., Cho, H.S., et al., Kim, Y.J., Hahn, J.H., and Oh, B.H., in 1998 in a paper entitled "High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TUMOR NECROSIS FACTOR-ALPHA. This molecule has the UniProt identifier P01375 (TNFA_HUMAN)search. The sample contained 150 residues which is < 90% of the natural sequence. Out of 150 residues 143 were observed and are deposited in the PDB.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TUMOR NECROSIS FACTOR-ALPHA P01375 (84-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 150 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (84 - 233) TUMOR NECROSIS FACTOR-ALPHA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A TNF-likesearch Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P01375) membranesearch immune responsesearch tumor necrosis factor receptor bindingsearch

Chain InterPro annotation
A Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch