› 4rz7

X-ray diffraction
2.35Å resolution

Crystal Structure of PVX_084705 with bound PCI32765

Released:
DOI: 10.2210/pdb4rz7/pdb
PDB entry 4rz7 coloured by chain, front view.
PDB entry 4rz7 coloured by chain, side view.
PDB entry 4rz7 coloured by chain, top view.
Source organism: Plasmodium vivax Sal-1
Entry authors: Jiang DQ, Tempel W, Loppnau P, Graslund S, He H, Seitova A, Arrowsmith CH, Edwards AM, Bountra C, Hui R, Hutchinson A, El Bakkouri M, Amani M, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cGMP-dependent protein kinase Chain: A
Molecule details ›
Chain: A
Length: 847 amino acids
Theoretical weight: 96.73 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A5K0N4 (Residues: 1-846; Coverage: 100%)
Gene names: PKG, PVX_084705
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 1E8 1 x 1E8
Ligand UNX 66 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 192.556Å b: 117.422Å c: 68.219Å
α: 90° β: 95.26° γ: 90°
R-values:
R R work R free
0.196 0.194 0.238
Expression system: Spodoptera frugiperda

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