› 4rmz

X-ray diffraction
2.2Å resolution

Crystal Structure of IRAK-4

Released:
DOI: 10.2210/pdb4rmz/pdb
PDB entry 4rmz coloured by chain, front view.
PDB entry 4rmz coloured by chain, side view.
PDB entry 4rmz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.
Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP
Structure 14 1835-44 (2006)
PMID: 17161373

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 307 amino acids
Theoretical weight: 34.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NWZ3 (Residues: 154-460; Coverage: 67%)
Gene name: IRAK4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand T20 2 x T20
2 modified residues:
Ligand TPO 4 x TPO
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: I222
Unit cell:
a: 87.73Å b: 116.81Å c: 140.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.236 0.296
Expression system: Spodoptera frugiperda

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Citations

15 review citations

Targeting innate immunity protein kinase signalling in inflammation.
Gaestel et al. (2009)
14 more

1 mention without citation

Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis.
Scarneo et al. (2022)