Function and Biology Details
Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
AMPK complex, alpha1-beta2-gamma1 variant (preferred)
PDBe Complex ID:
PDB-CPX-129097 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
5'-AMP-activated protein kinase catalytic subunit alpha-1
Molecule details ›
Chain: A
Length: 540 amino acids
Theoretical weight: 61.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 540 amino acids
Theoretical weight: 61.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q13131 (Residues: 20-559; Coverage: 97%)
Sequence domains:
5'-AMP-activated protein kinase subunit beta-2
Molecule details ›
Chain: B
Length: 197 amino acids
Theoretical weight: 22.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 197 amino acids
Theoretical weight: 22.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: O43741 (Residues: 76-272; Coverage: 72%)
Sequence domains:
5'-AMP-activated protein kinase subunit gamma-1
Molecule details ›
Chain: G
Length: 304 amino acids
Theoretical weight: 34.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: CBS domain
Length: 304 amino acids
Theoretical weight: 34.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P54619 (Residues: 24-327; Coverage: 92%)
Sequence domains: CBS domain
