4re1

X-ray diffraction
2.2Å resolution

Crystal structure of human TEAD1 and disulfide-engineered YAP

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-151214 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional enhancer factor TEF-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 220 amino acids
Theoretical weight: 25.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28347 (Residues: 209-426; Coverage: 51%)
Gene names: TCF13, TEAD1, TEF1
Sequence domains: YAP binding domain
Structure domains: Coagulation Factor XIII; Chain A, domain 1
Transcriptional coactivator YAP1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 149 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46937 (Residues: 50-171; Coverage: 24%)
Gene names: YAP1, YAP65
Structure domains: Virus Scaffolding Protein; Chain A

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 44.25Å b: 105.03Å c: 164.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.248
Expression system: Escherichia coli