› 4r77

X-ray diffraction
1.94Å resolution

Crystal structure of choline kinase LicA from Streptococcus pneumoniae

Released:
DOI: 10.2210/pdb4r77/pdb
PDB entry 4r77 coloured by chain, front view.
PDB entry 4r77 coloured by chain, side view.
PDB entry 4r77 coloured by chain, top view.
Source organism: Streptococcus pneumoniae
Primary publication:
Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae.
Wang L, Jiang YL, Zhang JR, Zhou CZ, Chen Y
PLoS One 10 e0120467 (2015)
PMID: 25781969

Function and Biology Details

Reaction catalysed: 
ATP + choline = ADP + phosphocholine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184132 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 35.61 KDa
Source organism: Streptococcus pneumoniae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8DPI4 (Residues: 1-289; Coverage: 100%)
Gene names: pck, spr1147
Sequence domains: Choline/ethanolamine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 69.347Å b: 96.466Å c: 97.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.255
Expression system: Escherichia coli

Quick links

Citations

1 review citation

ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents.
Khalifa et al. (2020)
4 other articles

7 mentions without citation

Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases.
Lacal et al. (2021)
6 more