› 4pdo

X-ray diffraction
2.1Å resolution

Structure of Ephrin type-A receptor 2

Released:
DOI: 10.2210/pdb4pdo/pdb
PDB entry 4pdo coloured by chain, front view.
PDB entry 4pdo coloured by chain, side view.
PDB entry 4pdo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jimin Z, Qiang W, Zongchao J

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 299 amino acids
Theoretical weight: 34.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29317 (Residues: 590-876; Coverage: 30%)
Gene names: ECK, EPHA2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P32
Unit cell:
a: 92.461Å b: 92.461Å c: 75.836Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.162 0.16 0.184
Expression system: Escherichia coli BL21(DE3)

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Citations

2 mentions without citation

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases.
Xu et al. (2015)
1 more