4p01 Summary

pdbe.org/4p01
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Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide

The structure was published by Pantouris, G. and Lolis, E., in in a paper entitled "to be published" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.07 Å and deposited in 2014.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Macrophage migration inhibitory factor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Macrophage migration inhibitory factor P14174 (2-115) (MIF_HUMAN)search Homo sapienssearch 98% 114 100%
B Macrophage migration inhibitory factor P14174 (2-115) (MIF_HUMAN)search Homo sapienssearch 98% 114 100%
C Macrophage migration inhibitory factor P14174 (2-115) (MIF_HUMAN)search Homo sapienssearch 98% 114 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14174 (2 - 115) Macrophage migration inhibitory factor Homo sapiens

Chain Sequence family (Pfam)
A, B, C (P14174) PF01187: Macrophage migration inhibitory factor (MIF)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C (P14174) inflammatory responsesearch cell proliferationsearch positive regulation of ERK1 and ERK2 cascadesearch negative regulation of DNA damage response, signal transduction by p53 class mediatorsearch positive regulation of peptidyl-tyrosine phosphorylationsearch cell agingsearch carboxylic acid metabolic processsearch negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorsearch positive regulation of fibroblast proliferationsearch negative regulation of cellular protein metabolic processsearch positive regulation of protein phosphorylationsearch cell surface receptor signaling pathwaysearch positive regulation of MAP kinase activitysearch positive regulation of lipopolysaccharide-mediated signaling pathwaysearch prostaglandin biosynthetic processsearch DNA damage response, signal transduction by p53 class mediatorsearch protein homotrimerizationsearch positive regulation of arachidonic acid secretionsearch negative regulation of gene expressionsearch positive regulation of myeloid leukocyte cytokine production involved in immune responsesearch positive regulation of peptidyl-serine phosphorylationsearch positive regulation of protein kinase A signalingsearch negative regulation of apoptotic processsearch negative regulation of mature B cell apoptotic processsearch positive regulation of cytokine secretionsearch negative regulation of myeloid cell apoptotic processsearch negative regulation of cell agingsearch regulation of cell proliferationsearch positive chemotaxissearch positive regulation of chemokine (C-X-C motif) ligand 2 productionsearch positive regulation of B cell proliferationsearch negative regulation of cell cycle arrestsearch innate immune responsesearch positive regulation of phosphorylationsearch positive regulation of prostaglandin secretion involved in immune responsesearch regulation of macrophage activationsearch immune system processsearch receptor bindingsearch chemoattractant activitysearch isomerase activitysearch cytokine activitysearch phenylpyruvate tautomerase activitysearch dopachrome isomerase activitysearch cytokine receptor bindingsearch protein bindingsearch extracellular regionsearch extracellular spacesearch extracellular vesicular exosomesearch vesiclesearch cytoplasmsearch cell surfacesearch

Chain InterPro annotation
A, B, C Macrophage migration inhibitory factorsearch Tautomerase/MIF superfamilysearch Macrophage migration inhibitory factor, conserved sitesearch