4p01 Summary

pdbe.org/4p01
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Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide

The structure was published by Pantouris, G. and Lolis, E., in in a paper entitled "to be published" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.07 Å and deposited in 2014.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Macrophage migration inhibitory factor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Macrophage migration inhibitory factor P14174 (2-115) (MIF_HUMAN)search Homo sapienssearch 98% 114 100%
B Macrophage migration inhibitory factor P14174 (2-115) (MIF_HUMAN)search Homo sapienssearch 98% 114 100%
C Macrophage migration inhibitory factor P14174 (2-115) (MIF_HUMAN)search Homo sapienssearch 98% 114 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14174 (2 - 115) Macrophage migration inhibitory factor Homo sapiens

Chain Sequence family (Pfam)
A, B, C (P14174) PF01187: Macrophage migration inhibitory factor (MIF)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C (P14174) cytokine activitysearch receptor bindingsearch chemoattractant activitysearch dopachrome isomerase activitysearch protein bindingsearch cytokine receptor bindingsearch phenylpyruvate tautomerase activitysearch isomerase activitysearch innate immune responsesearch cell proliferationsearch positive regulation of fibroblast proliferationsearch positive regulation of peptidyl-tyrosine phosphorylationsearch positive regulation of ERK1 and ERK2 cascadesearch regulation of cell proliferationsearch carboxylic acid metabolic processsearch negative regulation of DNA damage response, signal transduction by p53 class mediatorsearch negative regulation of myeloid cell apoptotic processsearch positive regulation of myeloid leukocyte cytokine production involved in immune responsesearch cell surface receptor signaling pathwaysearch negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorsearch negative regulation of gene expressionsearch negative regulation of apoptotic processsearch positive regulation of protein kinase A signalingsearch positive regulation of lipopolysaccharide-mediated signaling pathwaysearch protein homotrimerizationsearch prostaglandin biosynthetic processsearch positive regulation of cytokine secretionsearch DNA damage response, signal transduction by p53 class mediatorsearch immune system processsearch positive regulation of peptidyl-serine phosphorylationsearch positive chemotaxissearch positive regulation of arachidonic acid secretionsearch positive regulation of chemokine (C-X-C motif) ligand 2 productionsearch cell agingsearch negative regulation of cell agingsearch negative regulation of mature B cell apoptotic processsearch negative regulation of cellular protein metabolic processsearch regulation of macrophage activationsearch inflammatory responsesearch positive regulation of protein phosphorylationsearch positive regulation of B cell proliferationsearch positive regulation of MAP kinase activitysearch positive regulation of phosphorylationsearch negative regulation of cell cycle arrestsearch positive regulation of prostaglandin secretion involved in immune responsesearch extracellular regionsearch extracellular spacesearch cytoplasmsearch extracellular vesicular exosomesearch vesiclesearch cell surfacesearch

Chain InterPro annotation
A, B, C Macrophage migration inhibitory factorsearch Tautomerase/MIF superfamilysearch Macrophage migration inhibitory factor, conserved sitesearch