› 4ozu

X-ray diffraction
1.65Å resolution

Crystal Structure of WD40 domain from Toxoplasma gondii coronin

Released:
DOI: 10.2210/pdb4ozu/pdb
PDB entry 4ozu coloured by chain, front view.
PDB entry 4ozu coloured by chain, side view.
PDB entry 4ozu coloured by chain, top view.
Source organism: Toxoplasma gondii
Primary publication:
Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress.
Salamun J, Kallio JP, Daher W, Soldati-Favre D, Kursula I
FASEB J 28 4729-47 (2014)
PMID: 25114175

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coronin Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 43.45 KDa
Source organism: Toxoplasma gondii
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5Y1E7 (Residues: 2-392; Coverage: 63%)
Gene name: CRN1
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

2 bound ligands:
Ligand TRS 1 x TRS
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: C2221
Unit cell:
a: 55.13Å b: 82.51Å c: 156.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.163 0.202
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Gliding motility powers invasion and egress in Apicomplexa.
Frénal et al. (2017)
1 more

4 mentions without citation

Towards a molecular understanding of the apicomplexan actin motor: on a road to novel targets for malaria remedies?
Kumpula et al. (2015)
3 more