› 4ot9

X-ray diffraction
3.35Å resolution

crystal structure of the C-terminal domain of p100/NF-kB2

Released:
DOI: 10.2210/pdb4ot9/pdb
PDB entry 4ot9 coloured by chain, front view.
PDB entry 4ot9 coloured by chain, side view.
PDB entry 4ot9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation.
Tao Z, Fusco A, Huang DB, Gupta K, Young Kim D, Ware CF, Van Duyne GD, Ghosh G
Proc Natl Acad Sci U S A 111 15946-51 (2014)
PMID: 25349408

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169463 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear factor NF-kappa-B p52 subunit Chain: A
Molecule details ›
Chain: A
Length: 359 amino acids
Theoretical weight: 38.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00653 (Residues: 407-765; Coverage: 40%)
Gene names: LYT10, NFKB2
Sequence domains: Ankyrin repeat

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6322
Unit cell:
a: 196.67Å b: 196.67Å c: 68.46Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.233 0.272
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Role of the NFκB-signaling pathway in cancer.
Xia et al. (2018)
11 more

4 mentions without citation

Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors.
Walser et al. (2022)
3 more